This course is designed to guide graduate students applying different bioinformatic tools to launch genomic study. With real-world data and abundant information from public databases, those students will learn how to integrate and interpret gene expression and related function in gene level as well as in genomic level.

上課大綱：
第一週 History and Definition of Bioinformatics
第二週 Alignment of Pairs of Sequences (Global vs. Local vs. Semi-global)
第三週 Multiple Sequence Alignment
第四週 BLAST against Public Databases
第五週 Introduction to Public Databases (DB Interpretation project, 15%)
第六週 NCBI Databases
第七週 TIGR Databases
第八週 KEGG and WIT Databases
第九週 期中考 (25%)
第十週 Collection and Integration of data/information from experiments/databases
第十一週 EST project for livestock animals
第十二週 Quality Control of Genomic Study
第十三週 Gene Prediction: Methods and Evaluation
第十四週 Protein structure related issues (I) (Sequence Analysis project, 15%)
第十五週 Protein structure related issues (II)
第十六週 Data Analysis for Gene Expression (I)
第十七週 Data Analysis for Gene Expression (II)
第十八週 期末考 (25%)
平時作業、上課發問與回答問題 (20%)

參考書目：
Mount, D. W. 2004. Bioinformatics: Sequence and Genome Analysis. 2nd Ed. Published by: Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, U.S.A.
Baxevanis, A. D. and Francis Ouellette, B. F. (ed.) 2004. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. 3rd Ed. Published by: John Wiley & Son, Inc., NY, U.S.A.
Gibson, G and S. V. Muse. 2002. 基因體科學入門(中文譯版 2003)。編譯：曾銘仁、阮雪芬、李宗憲、吳嘉欽、陳韻如。審校：陳水田。出版：藝軒圖書出版社。
Canter, C. R. and C. L. Smith. 1999. Genomics: The Science and Technology Behind the Human Genome Project. Published by: John Wiley & Son, Inc., NY, U.S.A.